Mechanobiology Lab
Welcome to Han Lab!
We study mechanobiology, particularly on how adherent cells can sense and respond to mechanical stiffness of the extracellular matrix. To investigate this, we have established experimental and computational frameworks for force measurement and adhesion dynamics quantification. We apply these frameworks, with cutting edge computer vision technique, on live-cell microscope images to find out fundamental mechanism underlying mechanosensation in the normal cells and the biomechanical signature in the diseased cells whose signaling has gone awry.
News:
Aug 1, 2024: Dr. Han was promoted to Associate Professor, thanks to his team's hard work. Thank you!
Apr 24, 2024: Endothelial cells are sensitive to low shear in just a short time! Mohanish's paper about endothelial sensing of temporary low-shear stress has been published in AJP-Heart. TechToday Coverage.
Apr 18, 2024: Our microscope is re-assembled at the new HSTEM Building!
Mar 27, 2024: Our collaborative work with Steve McGowan at Iowa was published in the American Journal of Respiratory Cell and Molecular Biology. Good job, Mohanish!
Feb 29, 2024: We are in the new building! Good job everyone helping smooth transition to HSTEM Complex!
Jan 15, 2024: Nik's paper regarding myosin-independent ECM stiffness sensing has been published in Communications Materials, a Nature Portfolio Journal. Congrats!
Dec 17, 2023: Dr. Han was awarded a Wallace Research Foundation grant for the study of collagen type V's role in wound healing in vivo and in vitro.
March 3, 2023: Dr. Han was awarded an NIH R15 grant for linking mechanotransmission to mechanosignaling.
