Publications

IN-REVIEW OR PREPRINT

29.    Isogai, T., Dean, K.M., Roudot, P., Shao, Q., Cillay, J.D., Welf, E.S., Driscoll, M.K., Royer, S.P., Mittal, N., Chang, B., Han, S.J., Fiolka, R., Danuser, G., 2019. Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D . BioRxiv 

PEER REVIEWED PUBLICATIONS (in reverse chronological order) 

28.  Chandurkar, M. K., Mittal, N, Royer-Weeken, S. P., Lehmann, S. D., Michels, E. B., Haarman, S. E., Severance, S. A., Rho, Y., Han, S. J. (2024). Transient Low Shear Stress Preconditioning Influences Long-term Endothelial Traction and Alignment under High Shear Flow. American Journal of Physiology-Heart and Circulatory Physiology 326(5), H1180-H1192. Link

27.  McGowan, S.E., Gilfanov, N., Chandurkar, M. K., Stiber, J. A., Han, S. J. (2024). Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development. American Journal of Respiratory Cell and Molecular Biology 70(4). Link

26.  Mittal, N., Michels, E. B., Massey, A. E., Qiu, Y., Royer-Weeden, S. P., Smith, B.R.,  Cartagena-Rivera, A. X., Han, S. J. (2024). Myosin-independent stiffness sensing by fibroblasts is regulated by the viscoelasticity of flowing actin. Communications Materials 5(1), 6. Link

25.  Carney, K. R., Khan, A. M., Samson, S. C., Mittal, N., Han, S. J., Mendoza, M. C., & Bidone, T. C. (2023). Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism. Mol Biol Cell 34(12), ar115. Link

24.   Haarman, S., Kim, S. Y., Isogai, T., Dean, K. M., Han, S. J. (2022). Particle Retracking Algorithm Capable of Quantifying Large, Local Matrix Deformation for Traction Force Microscopy, PLoS One 17(6): e0268614. DOI: 10.1371/journal.pone.0268614. Link

23.  Wang, J., Wren, J.D., Ding, Y., Chen, J., Mittal, N., Xu, C., Li, X., Zeng, C., Wang, M., Shi, J., Zhang, Y.H., Han, S.J., and Zhang, X.A., (2022). EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer. Cancer letters, 536, p.215641.  Link

22.  Royer S. P., Han S. J., (2022). Mechanobiology in the Comorbidities of Ehlers Danlos Syndrome.  Frontiers in Cell and Developmental Biology, 10, 2296-634X, DOI: 10.3389/fcell.2022.874840   Link

21.  Beussman, K. M., Mollica, M. Y., Leonard, A., Miles, J., Hocter, J., Song, Z., …, Han, S.J., …, Wendy, E. T., & Sniadecki, N. J. (2021). Black Dots: High-Yield Traction Force Microscopy Reveals Structural Factors Contributing to Platelet Forces. Acta biomaterialia.   Link

20.  Mittal, N., & Han, S. J. (2021). High-resolution, highly-integrated traction force microscopy software. Current Protocols, 1, e233. doi: 10.1002/cpz1.233   Link

19.    Han, S. J.; Azarova, E. V.; Whitewood, A. J.; Bachir, A.; Guttierrez, E.; Groisman, A.; Horwitz, A. R.; Goult, B. T.; Dean, K. M.; Danuser, G. Pre-Complexation of Talin and Vinculin without Tension Is Required for Efficient Nascent Adhesion Maturation. eLife 2021, 10, e66151. https://doi.org/10.7554/eLife.66151.

18.    Schäfer, C., Ju, Y., Tak, Y., Vazquez, C., Han, S.J., Tan E., Shay J.W., Holmqvist M., Danuser G., Schopperle, W.M., Bubley, G., 2020. TRA-1-60-positive/CD45low cells found in the peripheral blood of prostate cancer patients with metastatic disease – A proof-of-concept study. Heliyon, 6(1)

17.     Mohan, A.S., Dean, K.M., Isogai, T., Kasitinon, S.Y., Murali, V.S., Roudot, P., Groisman, A., Reed, D.K., Welf, E.S., Han, S.J., Noh, J., and Danuser, G. 2019. Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Developmental Cell, 49(3), pp.444-460. 

16.     Costigliola, N., Ding, L., Burckhardt, C.J., Han, S.J., Gutierrez, E., Mota, A., Groisman, A., Mitchison, T.J., and Danuser, G. (2017) Vimentin directs traction stress. PNAS. 2017 114 (20) 5195-5200.

15.     Han, S.J., Rodriguez M.L., Al-Rekabi, Z., Sniadecki, N.J. (2016) Spatial and Temporal Coordination of Traction Forces In One-Dimensional Cell Migration, Cell Adhesion & Migration. 10(5): 529-539.

14.     Oudin, M.J., Barbier, L., Schäfer, C, Kosciuk, T., Miller, M.A., Han, S.J., Jonas, O., Lauffenburger, D.A., Gertler, F.B. (2016) Mena confers resistance to Paclitaxel in triple-negative breast cancer. Mol Cancer Ther. DOI: 10.1158/1535-7163. MCT-16-0413. 

13.     Milan,J., Manifacier, I., Beussman, K.M., Han, S.J., Sniadecki, N.J., About, I., Chabrand, P. (2016) In silico CDM model sheds light on force transmission in cell from focal adhesions to nucleus. J Biomechanics. 49(13):2625-2634. 

12.     Lomakin. A.J., Lee, K.C., Han, S.J., Bui, A., Davidson, M., Mogilner, A., Danuser G. (2015) Competition for molecular resources among two structurally distinct actin networks defines a bistable switch for cell polarization, Nature Cell Biology. 17, 1435–1445

11     Han, S.J., Oak, Y., Groisman, A., Danuser, G. (2015) Traction Microscopy to Identify Force Modulation in Sub-resolution Adhesions, Nature Methods. 12(7): 653–656

10.     Rodriguez, M.L., Graham, B.T., Pabon, L.M., Han, S.J., Murry, C.E., Sniadecki, N.J.  (2014) Measuring the Contractile Forces of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Arrays of Microposts. J Biomechanical Engineering. 136(5), 051005

9.     Sniadecki, N.J., Han, S.J., Ting, L.H., Feghhi, S. (2013) Micropatterning on Micropost Arrays, Methods in Cell Biology. 121:61-73 

8.  Rodriguez, A.G., Rodriguez, M.L., Han, S.J. Sniadecki, N.J., Regnier, M.  (2013) Enhanced Contractility with 2-deoxy-ATP and EMD 57033 is Correlated with Reduced Myofibril Structure and Twitch Power in Neonatal Cardiomyocytes. Integr Biol.  5(11):1366-73

7.  Han, S.J., Bielowski, K., Rodriguez, M, Ting, L., Sniadecki, N.J. (2012) Decoupling Spread Area, Substrate Stiffness, and Micropost Density: A Close Spatial Relationship Between Traction Forces and Focal Adhesions. Biophys J. 103(4):640-648

 6.  Ting, L., Jahn , J., Jung, J., Shuman, B., Feghhi, S., Han, S.J., Sniadecki, N.J. (2012) Flow Mechanotransduction Regulates Traction Forces, Intercellular Forces, and Adherens Junctions. Am J Physiol Heart and Cir Physiol. 302(11):H2220-H2229

5.  Ting, L.H., Feghhi, S., Han, S.J., Rodriguez, M.L., Sniadecki, N.J.  (2011) Effect of Silanization Film Thickness in Soft Lithography of Nanoscale Features. ASME J Nano Engr Medicine. 2(4):041006

4.  Rodriguez, A.G., Han, S.J., Regnier, M., Sniadecki, N.J.  (2011) Substrate Stiffness Increases Twitch Power of Neonatal Cardiomyocytes in Correlation with Changes in Myofibril Structure and Intracellular Calcium. Biophys J. 101(10):2455-2464. 

3.  Han, S.J., Sniadecki, N.J. (2011) Simulations of the Contractile Cycle in Cell Migration Using a Bio-Chemical-Mechanical Model. Comp Meth Biomech Biomed Eng.  14(5):459-468 

2.  Tooley, W.W., Feghhi, S., Han, S.J., Wang, J., Sniadecki, N.J. (2011) Thermal Fracture of Oxidized Polydimethylsiloxane during Soft Lithography of Nanopost Arrays. J Microeng Micromech. 21(5):054013 

1.  Liang, X.M, Han, S.J., Reems, J.A., Gao, D., Sniadecki, N.J. (2010) Platelet Retraction Force Measurements Using Flexible Post Force Sensors. Lab on a Chip. 10(8):991-998

BOOK CHAPTER

1.   Han, S.J., Sniadecki, N.J. (2011) Nanotechnology Usages for Cellular Adhesion and Traction Forces. Cellular and Biomolecular Mechanics and Mechanobiology.  (ed. A. Gefen). Springer: New York. 7:177-200. 

2.   Chandurkar M.K., Han S.J. (2022) Subcellular Force Quantification of Endothelial Cells Using Silicone Pillar Arrays. In: Zhao F., Leong K.W. (eds) Vascular Tissue Engineering. Methods in Molecular Biology, vol 2375. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1708-3_19

MANUSCRIPTS IN PREPARATION

1.   Halidy, N., Han, S.J., Vilela, M., Guttierrez, E., Groisman, A. and Danuser, G. Mechanical environment alters Rac1 and RhoA activity at the leading edge of a migrating cell. In preparation

2.   Lakoduk, A.M., Han, S.J., Kadlecova, Z., Schmid, S. The interaction of PIPKI gamma with AP2 regulates spatial and temporal focal adhesion dynamics in cells. In preparation